Publication
Publication

Sci Rep. 2023

Drosophila innate immunity suppresses the survival of xenografted mammalian tumor cells.
Aida A, Yuswan K, Kawai Y, Hasegawa K, Nakajima YI, Kuranaga E.
Sci Rep. 2023 Jul 30;13(1):12334. doi: 10.1038/s41598-023-38489-9.

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PLoS Genet. 2023

Damage sensing mediated by serine proteases Hayan and Persephone for Toll pathway activation in apoptosis-deficient flies.
Nakano S, Kashio S, Nishimura K, Takeishi A, Kosakamoto H, Obata F, Kuranaga E, Chihara T, Yamauchi Y, Isobe T, Miura M.
PLoS Genet. 2023 Jun 15;19(6):e1010761. doi: 10.1371/journal.pgen.1010761. eCollection 2023 Jun.

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Life Sci Alliance. 2023

Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generation.
Fujita H, Kaneshiro J, Takeda M, Sasaki K, Yamamoto R, Umetsu D, Kuranaga E, Higo S, Kondo T, Asano Y, Sakata Y, Miyagawa S, Watanabe TM.
Life Sci Alliance. 2023 May 26;6(7):e202302070. doi: 10.26508/lsa.202302070. Print 2023 Jul.

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Bioessays. 2023

Underlying mechanisms that ensure actomyosin-mediated directional remodeling of cell-cell contacts for multicellular movement: Tricellular junctions and negative feedback as new aspects underlying actomyosin-mediated directional epithelial morphogenesis: Tricellular junctions and negative feedback as new aspects underlying actomyosin-mediated directional epithelial morphogenesis.
Uechi H, Kuranaga E.
Bioessays. 2023 May;45(5):e2200211. doi: 10.1002/bies.202200211. Epub 2023 Mar 17.

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Sci Rep. 2022

siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos.
Masuda-Ozawa T, Fujita S, Nakamura R, Watanabe H, Kuranaga E, Nakajima YI.
Sci Rep. 2022 Sep 30;12(1):16049. doi: 10.1038/s41598-022-20476-1.

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J Vis Exp. 2022

Fluorescent In Situ Hybridization and 5-Ethynyl-2'-Deoxyuridine Labeling for Stem-like Cells in the Hydrozoan Jellyfish Cladonema pacificum.
Fujita S, Kuranaga E, Miura M, Nakajima YI.
J Vis Exp. 2022 Aug 3;(186). doi: 10.3791/64285.

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Nat Commun. 2022

Inhibition of negative feedback for persistent epithelial cell-cell junction contraction by p21-activated kinase 3.
Uechi H, Fukushima K, Shirasawa R, Sekine S, Kuranaga E.
Nat Commun. 2022 Jun 20;13(1):3520. doi: 10.1038/s41467-022-31252-0.

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Genes . 2021

Regeneration Potential of Jellyfish: Cellular Mechanisms and Molecular Insights.
Fujita S, Kuranaga E, Nakajima YI.
Genes (Basel). 2021 May 17;12(5):758. doi: 10.3390/genes12050758.

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Nat Commun. 2020

Differential cell adhesion implemented by Drosophila Toll corrects local distortions of the anterior-posterior compartment boundary.
Iijima N, Sato K, Kuranaga E, Umetsu D.
Nat Commun. 2020 Dec 10;11(1):6320. doi: 10.1038/s41467-020-20118-y.

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Development. 2020

Reduction of endocytic activity accelerates cell elimination during tissue remodeling of the Drosophila epidermal epithelium.
Hoshika S, Sun X, Kuranaga E, Umetsu D.
Development. 2020 Apr 14;147(7):dev179648. doi: 10.1242/dev.179648.

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PeerJ. 2019

Cell proliferation controls body size growth, tentacle morphogenesis, and regeneration in hydrozoan jellyfish Cladonema pacificum.
Fujita S, Kuranaga E, Nakajima YI.
PeerJ. 2019 Aug 26;7:e7579. doi: 10.7717/peerj.7579

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Dev Cell. 2019

The Tricellular Junction Protein Sidekick Regulates Vertex Dynamics to Promote Bicellular Junction Extension.
Uechi H, Kuranaga E.
Dev Cell. 2019 Aug 5;50(3):327-338.e5. doi: 10.1016/j.devcel.2019.06.017.

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Biophys J. 2019

Apical Junctional Fluctuations Lead to Cell Flow while Maintaining Epithelial Integrity.
Okuda S, Kuranaga E, Sato K.
Biophys J. 2019 Mar 19;116(6):1159-1170. doi: 10.1016/j.bpj.2019.01.039.

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Curr Opin Genet Dev. 2018

Mechanisms of unusual collective cell movement lacking a free front edge in Drosophila.
Uechi H, Kuranaga E.
Curr Opin Genet Dev. 2018 Aug;51:46-51. doi: 10.1016/j.gde.2018.06.012.

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Curr Biol. 2018

Competition for Space Is Controlled by Apoptosis-Induced Change of Local Epithelial Topology.
Tsuboi A, Ohsawa S, Umetsu D, Sando Y, Kuranaga E, Igaki T, Fujimoto K.
Curr Biol. 2018 Jul 9;28(13):2115-2128.e5. doi: 10.1016/j.cub.2018.05.029.

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Mol Cell Biol. 2018

Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila.
Uechi H, Kuranaga E, Iriki T, Takano K, Hirayama S, Miura M, Hamazaki J, Murata S.
Mol Cell Biol. 2018 Jan 16;38(3). pii: e00195-17. doi: 10.1128/MCB.00195-17.

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Front Cell Dev Biol. 2017

Inference of Cell Mechanics in Heterogeneous Epithelial Tissue Based on Multivariate Clone Shape Quantification.
Tsuboi A, Umetsu D, Kuranaga E, Fujimoto K.
Front Cell Dev Biol. 2017 Aug 3;5:68. doi: 10.3389/fcell.2017.00068.

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Front Cell Dev Biol. 2017

Inference of Cell Mechanics in Heterogeneous Epithelial Tissue Based on Multivariate Clone Shape Quantification.
Tsuboi A, Umetsu D, Kuranaga E, Fujimoto K.
Front Cell Dev Biol. 2017 Aug 3;5:68. doi: 10.3389/fcell.2017.00068. eCollection 2017.

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Cell Mol Life Sci. 2017

Mechanisms of collective cell movement lacking a leading or free front edge in vivo.
Uechi H, Kuranaga E.
Cell Mol Life Sci. 2017 Aug;74(15):2709-2722. doi: 10.1007/s00018-017-2489-x.

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Curr Opin Genet Dev. 2017

Planar polarized contractile actomyosin networks in dynamic tissue morphogenesis.
Umetsu D, Kuranaga E.
Curr Opin Genet Dev. 2017 Aug;45:90-96. doi: 10.1016/j.gde.2017.03.012.

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Cell Death Differ. 2017

Caspase-dependent non-apoptotic processes in development.
Nakajima YI, Kuranaga E.
Cell Death Differ. 2017 Aug;24(8):1422-1430. doi: 10.1038/cdd.2017.36.

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Front Cell Dev Biol. 2017

Wave Propagation of Junctional Remodeling in Collective Cell Movement of Epithelial Tissue: Numerical Simulation Study.
Hiraiwa T, Kuranaga E, Shibata T.
Front Cell Dev Biol. 2017 Jul 19;5:66. doi: 10.3389/fcell.2017.00066. eCollection 2017.

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Int J Mol Sci. 2016

Apoptosis in Cellular Society: Communication between Apoptotic Cells and Their Neighbors.
Kawamoto Y, Nakajima YI, Kuranaga E.
Int J Mol Sci. 2016 Dec 20;17(12). pii: E2144. doi: 10.3390/ijms17122144.

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Nat Commun. 2015

Left-right asymmetric cell intercalation drives directional collective cell movement in epithelial morphogenesis.
Sato K, Hiraiwa T, Maekawa E, Isomura A, Shibata T, Kuranaga E.
Nat Commun. 2015 Dec 10;6:10074. doi: 10.1038/ncomms10074.

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Cell Rep. 2014

Single-cell imaging of caspase-1 dynamics reveals an all-or-none inflammasome signaling response.
Liu T, Yamaguchi Y, Shirasaki Y, Shikada K, Yamagishi M, Hoshino K, Kaisho T, Takemoto K, Suzuki T, Kuranaga E, Ohara O, Miura M.
Cell Rep. 2014 Aug 21;8(4):974-82. doi: 10.1016/j.celrep.2014.07.012.

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Cell Rep. 2014

Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis.
Obata F, Kuranaga E, Tomioka K, Ming M, Takeishi A, Chen CH, Soga T, Miura M.
Cell Rep. 2014 May 8;7(3):821-33.

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J Biol Chem. 2014

Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila.
Ming M, Obata F, Kuranaga E, Miura M.
J Biol Chem. 2014 Mar 14;289(11):7558-68.

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Cell Rep. 2013

Homeostatic epithelial renewal in the gut is required for dampening a fatal systemic wound response in Drosophila.
Takeishi A, Kuranaga E, Tonoki A, Misaki K, Yonemura S, Kanuka H, Miura M.
Cell Rep. 2013 Mar 28;3(3):919-30.

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Mol Cell. 2012

The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.
Sekine Y, Hatanaka R, Watanabe T, Sono N, Iemura S, Natsume T, Kuranaga E, Miura M, Takeda K, Ichijo H.
Mol Cell. 2012 Dec 14;48(5):692-704.

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Genes Cells. 2012

Beyond apoptosis: caspase regulatory mechanisms and functions in vivo.
Kuranaga E.
Genes Cells. 2012 Feb;17(2):83-97.

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Development. 2011

Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia.
Kuranaga E, Matsunuma T, Kanuka H, Takemoto K, Koto A, Kimura K, Miura M.
Development. 2011;138(8):1493-9.

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J Cell Sci. 2011

p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.
Sekine Y, Takagahara S, Hatanaka R, Watanabe T, Oguchi H, Noguchi T, Naguro I, Kobayashi K, Tsunoda M, Funatsu T, Nomura H, Toyoda T, Matsuki N, Kuranaga E, Miura M, Takeda K, Ichijo H.
J Cell Sci. 2011 ;124(Pt 17):3006-16.

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Curr Biol. 2011

Apoptosis ensures spacing pattern formation of Drosophila sensory organs.
Koto A, Kuranaga E, Miura M.
Curr Biol. 2011;21(4):278-87.

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Mol Cell Biol. 2011

Nonautonomous apoptosis is triggered by local cell cycle progression during epithelial replacement in Drosophila.
Nakajima Y, Kuranaga E, Sugimura K, Miyawaki A, Miura M.
Mol Cell Biol. 2011;31(12):2499-512.

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Genes Cells. 2011

Aging causes distinct characteristics of polyglutamine amyloids in vivo.
Tonoki A, Kuranaga E, Ito N, Nekooki-Machida Y, Tanaka M, Miura M.
Genes Cells. 2011;16(5):557-64.

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Dev Growth Differ. 2011

Caspase signaling in animal development.
Kuranaga E.
Dev Growth Differ. 2011;53(2):137-48. Review.

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J Am Chem Soc. 2011

β-Galactosidase fluorescence probe with improved cellular accumulation based on a spirocyclized rhodol scaffold.
Kamiya M, Asanuma D, Kuranaga E, Takeishi A, Sakabe M, Miura M, Nagano T, Urano Y.
J Am Chem Soc. 2011;133(33):12960-3.

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J Cell Sci. 2011

p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.
Sekine Y, Takagahara S, Hatanaka R, Watanabe T, Oguchi H, Noguchi T, Naguro I, Kobayashi K, Tsunoda M, Funatsu T, Nomura H, Toyoda T, Matsuki N, Kuranaga E, Miura M, Takeda K, Ichijo H.
J Cell Sci. 2011;124(Pt 17):3006-16.

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J Cell Biol. 2009

Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development.

Koto A, Kuranaga E, Miura M.
J Cell Biol. 2009;187(2):219-31.

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Mol Cell Biol. 2009

Genetic evidence linking age-dependent attenuation of the 26S proteasome with the aging process.
Tonoki A, Kuranaga E, Tomioka T, Hamazaki J, Murata S, Tanaka K, Miura M.
Mol Cell Biol. 2009;29(4):1095-106.

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Biosci Biotechnol Biochem. 2008

RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila.
Murata T, Suzuki E, Ito S, Sawatsubashi S, Zhao Y, Yamagata K, Tanabe M, Fujiyama S, Kimura S, Ueda T, Matsukawa H, Kouzmenko A, Furutani T, Kuranaga E, Miura M, Takeyama K, Kato S.
Biosci Biotechnol Biochem. 2008;72(9):2255-61.

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Proc Natl Acad Sci U S A. 2007

Local initiation of caspase activation in Drosophila salivary gland programmed cell death in vivo.
Takemoto K, Kuranaga E, Tonoki A, Nagai T, Miyawaki A, Miura M.
Proc Natl Acad Sci U S A. 2007;104(33):13367-72.

Dev Cell. 2007

Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila.
Xue L, Igaki T, Kuranaga E, Kanda H, Miura M, Xu T.
Dev Cell. 2007;13(3):446-54.

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J Cell Biol. 2007

DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells.
Ribeiro PS, Kuranaga E, Tenev T, Leulier F, Miura M, Meier P.
J Cell Biol. 2007;179(7):1467-80.

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Trends Cell Biol. 2007

Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination.
Kuranaga E, Miura M.
Trends Cell Biol. 2007;17(3):135-44. Review.

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Cell. 2006

Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs.
Kuranaga E, Kanuka H, Tonoki A, Takemoto K, Tomioka T, Kobayashi M, Hayashi S, Miura M.
Cell. 2006 ;126(3):583-96.

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Curr Biol. 2006

IKK epsilon regulates F actin assembly and interacts with Drosophila IAP1 in cellular morphogenesis.
Oshima K, Takeda M, Kuranaga E, Ueda R, Aigaki T, Miura M, Hayashi S.
Curr Biol. 2006;16(15):1531-7.

EMBO J. 2005

Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development.
Kanuka H, Kuranaga E, Takemoto K, Hiratou T, Okano H, Miura M.
EMBO J. 2005;24(21):3793-806.

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Biochim Biophys Acta. 2005

Gain-of-function screen identifies a role of the Sec61alpha translocon in Drosophila postmitotic neurotoxicity.
Kanuka H, Hiratou T, Igaki T, Kanda H, Kuranaga E, Sawamoto K, Aigaki T, Okano H, Miura M.
Biochim Biophys Acta. 2005;1726(3):225-37.

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Cell Death Differ. 2005

Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneration.
Nelson B, Nishimura S, Kanuka H, Kuranaga E, Inoue M, Hori G, Nakahara H, Miura M.
Cell Death Differ. 2005 Aug;12(8):1115-23.

Med Mol Morphol. 2005

Genetic approaches for the identification of apoptotic components.
Kuranaga E, Miura M.
Med Mol Morphol. 2005;38(1):18-22.

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Proc Natl Acad Sci U S A. 2003

Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila.
Kanuka H, Kuranaga E, Hiratou T, Igaki T, Nelson B, Okano H, Miura M.
Proc Natl Acad Sci U S A. 2003;100(20):11723-8.

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Nat Cell Biol. 2002

Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.
Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, Miura M.
Nat Cell Biol. 2002;4(9):705-10.

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EMBO J. 2002

Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway.
Igaki T, Kanda H, Yamamoto-Goto Y, Kanuka H, Kuranaga E, Aigaki T, Miura M.
EMBO J. 2002;21(12):3009-18.

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Arch Histol Cytol. 2002

Molecular genetic control of caspases and JNK-mediated neural cell death.
Kuranaga E, Miura M.
Arch Histol Cytol. 2002;65(4):291-300. Review.

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FEBS Lett. 2000

Requirement of the Fas ligand-expressing luteal immune cells for regression of corpus luteum.
Kuranaga E, Kanuka H, Furuhata Y, Yonezawa T, Suzuki M, Nishihara M, Takahashi M.
FEBS Lett. 2000;472(1):137-42.

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FEBS Lett. 2000

Progesterone is a cell death suppressor that downregulates Fas expression in rat corpus luteum.
Kuranaga E, Kanuka H, Hirabayashi K, Suzuki M, Nishihara M, Takahashi M.
FEBS Lett. 2000;466(2-3):279-82.

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Physiol Behav. 2000

Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats.
Suzuki M, Bannai M, Matsumuro M, Furuhata Y, Ikemura R, Kuranaga E, Kaneda Y, Nishihara M, Takahashi M.
Physiol Behav. 2000;68(5):707-13.

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Biochem Biophys Res Commun. 1999

Fas/Fas ligand system in prolactin-induced apoptosis in rat corpus luteum: possible role of luteal immune cells.
Kuranaga E, Kanuka H, Bannai M, Suzuki M, Nishihara M, Takahashi M.
Biochem Biophys Res Commun. 1999;260(1):167-73.

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